OK maybe I was trolling the audience a tiny bit there. Or myself. Mostly I found the prospect of duelling inhibitors and enhancers to be hilarious, but reality is never so neat, as several interlocutors of fine taste and discernment quite rightly commented.
In fact, while the SSRIs do inhibit serotonin reuptake, this is probably not how they actually work; hell, it's not entirely clear that they work significantly better than sugar pills. Similarly, if you followed the link to the article on tianeptine, you saw that it's now thought to act via glutamate receptors, not serotonin.
Finally, while rational drug discovery has led to some very silly situations in psychopharmacology, it's been very successful in other areas, and psychopharmacology is really mindblowingly difficult, so it's not really fair to attack it the way I did.
Also I am a big dumb head. But I still think the pixie joke was good.